February 25, 2024 –

February 27, 2024

Fifth Annual Workshop: Developing Tools for the Coming Therapeutic Era: Are We Getting Closer to Precision Medicine in Dementia Care?

Scientific Planning Committee

Dr. Gary Rosenberg, Program Co-Chair

Dr. Paulo Pires, Program Co-Chair

Susan Brogan, BBDI Executive Director, Program Co-Chair

February 26, 2024

8:45 am

Welcome

Frank Barone

8:50 am

Introduction: Setting the table

Paulo Pires and Gary Rosenberg

9:00 am

What is the blood-brain barrier and how is it measured in humans?

Gary Rosenberg

9:35 am

Blood-brain barrier dynamics in vascular dementia: Unravelling the tripartite crosstalk between the endothelium, pericytes, and microglia

Conor McQuaid

9:50 am

Cerebrovascular reactivity as a candidate biomarker in small vessel disease related VCID

Hanzhang Lu

10:30 am

Endothelial transient receptor potential vanilloid 4 channel deletion causes cognitive dysfunction in adult male and female mice

Anne Dorrance

10:55 am

Blood proteomic signatures of brain barrier dysfunction in aging and Alzheimer's disease

Fanny Elahi

11:20 am

Impaired drainage through capillary-venous networks contributed to aged-related white matter loss

Andy Shih

11:45 am

PIP2 as a therapeutic target for cerebral small vessel diseases

Masayo Koide

1:25 pm

Astrocyte zones in white matter stroke, repair and fibrosis

Tom Carmichael

1:50 pm

Cerebral white matter free water in VCID

Pauline Maillard

2:15 pm

PAA: The other cerebral amyloidosis

Greg Jicha

2:35 pm

Discussion: Making an impact with our research, how do we do it?

Greg Jicha

February 27, 2024

9:40 am

The future of the science of vascular contributions to cognitive impairment and dementia

Rod Corriveau

10:35 am

Considering VCID in the use of anti-Abeta immunotherapies

Erica Weekman

11:00 am

Blood-based neuroinflammation and vascular processes as “state markers” of amyloid and tau pathologies in AD

Thomas Karikari

12:45 pm

Developing tools for the coming therapeutic era: Are we getting closer to precision medicine in dementia care?

Phil Gorelick

1:05 pm

Nitro-oxidation of BKCa mediates neuro- and micro-vascular dysfunction in female 5x-FAD mice

Paulo Pires

1:30 pm

A lipid-centric cascade of Alzheimer's disease pathologies

Fei Yin

1:55 pm

Inflammatory mechanisms in small vessel disease: Insights from CAA and ARIA

Mariel Kozberg

2:30 pm

The amyloid-tau-neuroinflammation axis in the context of cerebral amyloid angiopathy

Cristian Lasagna-Reeves

2:55 pm

What do we do now? How do we do it?

Group